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mct1  (Santa Cruz Biotechnology)


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    Santa Cruz Biotechnology mct1
    Acid adaptation and p53 KO alter protein expression of acid-base transporters At week 11, WT and p53KO organoids grown under Ctrl, AA, or AA->7.4 conditions as in were lysed and subjected to western blot analysis for proteins relevant to acid-base homeostasis. Representative western blots are shown on the left, panels on the right show the corresponding densitometric quantifications, as means with S.E.M. error bars and biological replicates shown as open circles. β-actin is used as loading control. A(i) NHE1, NBCn1 western blots, (ii) and (iii), Quantifications of relative NHE1 and NBCn1 levels, respectively. B(i) <t>MCT1,</t> MCT4 western blots, (ii) and (iii), Quantifications of relative MCT1 and MCT4 levels, respectively. C(i) Slc26a6, CFTR western blots, (ii) and (iii), Quantifications of relative Slc26a6 and CFTR levels, respectively. Data represent 3–8 independent biological repeats per condition/protein. Statistical analysis: two-way ANOVA, with Tukey’s post test.
    Mct1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 269 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mct1/product/Santa Cruz Biotechnology
    Average 95 stars, based on 269 article reviews
    mct1 - by Bioz Stars, 2026-06
    95/100 stars

    Images

    1) Product Images from "Microenvironmental acidosis drives PARP- and ATM inhibitor resistance in p53 deficient pancreatic cancer"

    Article Title: Microenvironmental acidosis drives PARP- and ATM inhibitor resistance in p53 deficient pancreatic cancer

    Journal: iScience

    doi: 10.1016/j.isci.2026.115112

    Acid adaptation and p53 KO alter protein expression of acid-base transporters At week 11, WT and p53KO organoids grown under Ctrl, AA, or AA->7.4 conditions as in were lysed and subjected to western blot analysis for proteins relevant to acid-base homeostasis. Representative western blots are shown on the left, panels on the right show the corresponding densitometric quantifications, as means with S.E.M. error bars and biological replicates shown as open circles. β-actin is used as loading control. A(i) NHE1, NBCn1 western blots, (ii) and (iii), Quantifications of relative NHE1 and NBCn1 levels, respectively. B(i) MCT1, MCT4 western blots, (ii) and (iii), Quantifications of relative MCT1 and MCT4 levels, respectively. C(i) Slc26a6, CFTR western blots, (ii) and (iii), Quantifications of relative Slc26a6 and CFTR levels, respectively. Data represent 3–8 independent biological repeats per condition/protein. Statistical analysis: two-way ANOVA, with Tukey’s post test.
    Figure Legend Snippet: Acid adaptation and p53 KO alter protein expression of acid-base transporters At week 11, WT and p53KO organoids grown under Ctrl, AA, or AA->7.4 conditions as in were lysed and subjected to western blot analysis for proteins relevant to acid-base homeostasis. Representative western blots are shown on the left, panels on the right show the corresponding densitometric quantifications, as means with S.E.M. error bars and biological replicates shown as open circles. β-actin is used as loading control. A(i) NHE1, NBCn1 western blots, (ii) and (iii), Quantifications of relative NHE1 and NBCn1 levels, respectively. B(i) MCT1, MCT4 western blots, (ii) and (iii), Quantifications of relative MCT1 and MCT4 levels, respectively. C(i) Slc26a6, CFTR western blots, (ii) and (iii), Quantifications of relative Slc26a6 and CFTR levels, respectively. Data represent 3–8 independent biological repeats per condition/protein. Statistical analysis: two-way ANOVA, with Tukey’s post test.

    Techniques Used: Expressing, Western Blot, Control



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    Acid adaptation and p53 KO alter protein expression of acid-base transporters At week 11, WT and p53KO organoids grown under Ctrl, AA, or AA->7.4 conditions as in were lysed and subjected to western blot analysis for proteins relevant to acid-base homeostasis. Representative western blots are shown on the left, panels on the right show the corresponding densitometric quantifications, as means with S.E.M. error bars and biological replicates shown as open circles. β-actin is used as loading control. A(i) NHE1, NBCn1 western blots, (ii) and (iii), Quantifications of relative NHE1 and NBCn1 levels, respectively. B(i) <t>MCT1,</t> MCT4 western blots, (ii) and (iii), Quantifications of relative MCT1 and MCT4 levels, respectively. C(i) Slc26a6, CFTR western blots, (ii) and (iii), Quantifications of relative Slc26a6 and CFTR levels, respectively. Data represent 3–8 independent biological repeats per condition/protein. Statistical analysis: two-way ANOVA, with Tukey’s post test.
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    Image Search Results


    Acid adaptation and p53 KO alter protein expression of acid-base transporters At week 11, WT and p53KO organoids grown under Ctrl, AA, or AA->7.4 conditions as in were lysed and subjected to western blot analysis for proteins relevant to acid-base homeostasis. Representative western blots are shown on the left, panels on the right show the corresponding densitometric quantifications, as means with S.E.M. error bars and biological replicates shown as open circles. β-actin is used as loading control. A(i) NHE1, NBCn1 western blots, (ii) and (iii), Quantifications of relative NHE1 and NBCn1 levels, respectively. B(i) MCT1, MCT4 western blots, (ii) and (iii), Quantifications of relative MCT1 and MCT4 levels, respectively. C(i) Slc26a6, CFTR western blots, (ii) and (iii), Quantifications of relative Slc26a6 and CFTR levels, respectively. Data represent 3–8 independent biological repeats per condition/protein. Statistical analysis: two-way ANOVA, with Tukey’s post test.

    Journal: iScience

    Article Title: Microenvironmental acidosis drives PARP- and ATM inhibitor resistance in p53 deficient pancreatic cancer

    doi: 10.1016/j.isci.2026.115112

    Figure Lengend Snippet: Acid adaptation and p53 KO alter protein expression of acid-base transporters At week 11, WT and p53KO organoids grown under Ctrl, AA, or AA->7.4 conditions as in were lysed and subjected to western blot analysis for proteins relevant to acid-base homeostasis. Representative western blots are shown on the left, panels on the right show the corresponding densitometric quantifications, as means with S.E.M. error bars and biological replicates shown as open circles. β-actin is used as loading control. A(i) NHE1, NBCn1 western blots, (ii) and (iii), Quantifications of relative NHE1 and NBCn1 levels, respectively. B(i) MCT1, MCT4 western blots, (ii) and (iii), Quantifications of relative MCT1 and MCT4 levels, respectively. C(i) Slc26a6, CFTR western blots, (ii) and (iii), Quantifications of relative Slc26a6 and CFTR levels, respectively. Data represent 3–8 independent biological repeats per condition/protein. Statistical analysis: two-way ANOVA, with Tukey’s post test.

    Article Snippet: MCT1 , Santa Cruz Biotechnology , Sc-365501, RRID: AB_2943297.

    Techniques: Expressing, Western Blot, Control